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Nov. 24, 2011 Can computer models based on fundamental laws assist the treatment for cancers?Over the last decade, scientists have been intensely investigating on TRAIL, a protein released by our immune system, to treat malignant cancers. The benefit of using TRAIL, as compared to conventional chemo therapies, is that it specifically destroys carcinomas without affecting the surrounding normal tissues. This is done through a mechanism known as the programmed cell death or apoptosis. However, the TRAIL-based treatments so far have not been overtly successful as many carcinomas are able to ‘cheat’ the death signal, triggered by the TRAIL, into a survival signal.
A team of scientists from IAB, Keio University in Japan have formulated a method using a computational model and, with its aid,
predict a novel target that would in return cheat the cancer cells to switch from survival to apoptosis mode. The work of Dr Selvarajoo and colleagues, utilizing the fundamental physical law of conservation, pinpoints an intracellular target, whose removal will reroute most of the resultant signaling flux of TRAIL into a predetermined direction along the caspases-induced death pathway. Their findings are published in Scientific Reports, a newly launched journal of the Nature Publishing Group. Detail >> http://www.nature.com/srep/2011/111107/srep00144/full/srep00144.html |
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Mar. 10, 2011 Serum Metabolomics Reveals γ-Glutamyl Dipeptides as Biomarkers for Discrimination among Different Forms of Liver Disease Prof. Tomoyoshi Soga and Dr.Masahiro Sugimoto of IAB working in collaboration with a group of researchers including Prof. Makoto Suematu of School of Medicine, Keio University , Dr.Takafumi Saito of Department of Gastroenterology, Yamagata University School of Medicine and Dr.Masahi Honma of Department of Pharmacy, The University of Tokyo Hospital, has discovered reliable biomarkers for rapid screening diagnosis of liver diseases.
The article of this discovery will be published in Journal of Hepatology. http://www.jhep-elsevier.com/article/S0168-8278(11)00159-0/abstract |
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Dec. 17, 2010 Nice Step Researcher Award 2010
Mr.Junichi Sugahara(Doctoral couse student of IAB) and Mr.Kazuhide Sekiyama(President of Spiber Inc., graduated from IAB) won Nice Step Researcher Award 2010 of National Institute of Science and Technology Policy, MEXT. |
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Nov. 1, 2010 One big step toward the physical check-up with saliva in Yamagata prefecture
Yamagata Dental Association (President: Dr.Keiichi Ishiguro) and IAB launched the research group to start the physical check-up with saliva near future. |
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Oct. 27, 2010 Metabolome Analysis elucidates the change of taste of Dadacha-mame scientifically
IAB analyzed how metabolites change and how it influences to the taste by Metabolome analysis, when they're preserved. This is a collaborative research project with JA Tsuruoka (Tsuroka city, President : Mr.Imano) and Shonai division Yamagata prefecture(Mikawa town, President: Mr.Toshio Aida) to seek the best condition to preserve Dadacha-mame. |
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Oct. 20, 2010 Metabolome analysis reveals the components of taste & flavor of Dadacha-mameIAB analyzed the components of taste & flavor of Dadacha-mame(local variety of green soybeans) by Metabolome analysis. This is a collaborative research project with Yamagata University (Dr.Hiroaki Egashira, Faculty of Agriculture) and RIKEN PSC(Dr.Kazuki Saito). |
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Oct.18, 2010 Metabolome analysis reveals the components of good taste of "Tsuyahime", new brand rice of Yamagata prefecture IAB reveals the components of good taste of "Tsuyahime", new brand rice of Yamagata prefecture, by Metabolome analysis. This is a collaborative research project with Yamagata Integrated Agricultural Research Center. |
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Sep 12, 2010 IAB 10th anniversary event heldIAB's 10th anniversary event "Tsuruoka city, Yamaga prefecture as a world-famous educational & cultural city" was held at MARICA citizen hall, Tsuruoka City on September 12, 2010(Sunday). Dr.Masaru Tomita, Director of IAB presented our research & educational acitivities since 2001. Ms.Mieko Yoshimura(Governor of Yamagata prefecutre), Mr.Masaki Enomoto(Mayor of Tsuruoka city), Dr.Masahiro Kuroda (President of Tohoku University of Community Service and Science), Mr.Ryuji Kanno(President of Human Metabolome Technologies), Mr.Kazuhide Sekiyama (President of Spiber Inc.) ,Dr.Atsushi Seike (President of Keio University) and Dr.Tomita had the panel discussion about the future application of Systems Biology and revitalization of Tsuruoka city. Over 350 citizens had attended this seminar. Program (Japanese) & more photos >> |
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Sep 11, 2010 Dr.Nakada wins the BSJ Award for Junior Young Scientists at the Botanical Society of JapanDr.Takashi Nakada(research associate) received the BSJ Award for Junior Young Scientists at the 74th Annual Meeting of the Botanical Society of Japan(Sep 9-11, 2010). |
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Sep 11, 2010 Fifth Metabolome Symposium The Fifth Metabolome Symposium was held at Grand-el-sun, Tsuruoka City on Sep 9-11, 2010. 29 oral presentations and 54 poster presentations presented. About 250 participants from all over Japan gathered to Tsuruoka Japan. Program (Japanese only) >> |
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Aug 21, 2010 Special Seminar "Future of Cancer care" held at Yamagata CitySpecial seminar "Future of Cancer care" was held at Yamagata City on August 21, 2010(Saturday). (Co-host:Tsuruoka Medical Association, Shonai hospital, Tsuruoka city and IAB). This seminar was held for the first time in Yamagata city to introduce the leading-edge cancer study “Project of Early Clinical Development for Anti Cancer Medicine and Device” which is being developed in IAB to the public. This project led by Dr.Hiroyasu Esumi, Director of National Cancer Center Hospital East, was selected as “Super Special Consortia for supporting the development of cutting-edge medical care” by the Cabinet Office of the Japanese government in Nov 2008.(news ) Over 150 citizens had attended this seminar. Program (Japanese) >>
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