3D Cell Atlas Project

This project utilizes in-house technology to accurately capture 3D images of tissue morphology in resin/paraffin blocks. Specifically, a combination of cameras and sensors is used to semi-automatically acquire serial sections and serial photographs of the block surface. This enables the analysis of the position of the obtained tissue sections in relation to the entire tissue. Using this technology, we are developing a "3D cell atlas" that includes information on cell membranes, which is difficult to obtain using other methods. Additionally, by collecting histology data alongside the correct 3D morphology of tissues, we are using these datasets as training data for machine learning, with the end goal of reconstructing the morphology of specimens from microtome data for which the 3D shape is unknown, and combining it with spatial proteome analysis.

Publication

1. JETI, Vol. 70, No. 2 (2022)

2. Press release, (2021)

3. Scientific reports, 11, 13108 (2021)

Josephine GALIPON
Project Associate Professor
（Yamagata University Faculty of Engineering
　Associate Professor）

Takeshi Masuda
Project Assistant Professor

Taro Maeda
Project Research Associate

Yuki Tajika
advisor

（Gunma Prefectural College of Health Sciences
Associate Professor）