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Metabolomics Project
It has been extremely difficult to measure all metabolites (metabolome) because thousands of metabolites exist in cells and tissues, and further their physical and chemical properties are ranged from similar to completely different. We have developed the CE-MS method and pioneered the simultaneous analysis of thousands of charged metabolites. Currently, we are developing technologies for the measurement of neutral and lipid metabolites by LC-MS and SFC-MS methods, highly sensitive measurement technologies that enable the measurement of single-cell metabolomics by IC-MS and sheathless CE-MS methods, and high-throughput measurement technologies by multiple-sample injection CE-MS method, etc. These analytical technologies are being applied to samples such as microorganisms, plants, mammals, and human clinical specimens so that we contribute to the development of various fields ranging from basic life science research to fermentation, food, agriculture, medicine, pharmacy, and diagnostics.
Project HP URL:https://metabolome.iab.keio.ac.jp/ja/
Publication
- Anal. Chem. 92, 9799-9806. (2020)
- J. Chromatogr. A 1619, 460914. (2020)
- Electrophoresis 39, 1382-1389. (2018)
- J. Chromatogr. A 1369, 161-169. (2014)
- Analyst 137, 5026-5033. (2012)
- Anal. Chem. 81, 6165-6174. (2009)
- J. Biol. Chem. 281, 16768-16776. (2006)
- J. Proteome Res. 2, 488-494. (2003)
- Anal. Chem., 74, 2233-2239. (2002)
Tomoyoshi Soga
Professor
Akiyoshi Hirayama
Associate Professor
- List of research projects
- Molecular Anhydrobiology Project
- Protein Materials Project
- 3D Cell Atlas Project
- Environmental systems biology Project
- Stolen-phenotype biology Project
- Functional RNA Analysis Project
- Bacterial regulatory RNA project
- Synthetic Biology Project
- Bio-Functional Design Project
- Metabolomics Project
- Extracellular vesicle molecular function research Project
- Bioenergetic regulation Project
- DNA damage response Project
- Molecular Oncology Project
- Cancer Metabolism Project
- Tsuruoka Metabolomics Cohort Study (TMCS) Project