Metabolomics Project

It has been extremely difficult to measure all metabolites (metabolome) because thousands of metabolites exist in cells and tissues, and further their physical and chemical properties are ranged from similar to completely different. We have developed the CE-MS method and pioneered the simultaneous analysis of thousands of charged metabolites. Currently, we are developing technologies for the measurement of neutral and lipid metabolites by LC-MS and SFC-MS methods, highly sensitive measurement technologies that enable the measurement of single-cell metabolomics by IC-MS and sheathless CE-MS methods, and high-throughput measurement technologies by multiple-sample injection CE-MS method, etc. These analytical technologies are being applied to samples such as microorganisms, plants, mammals, and human clinical specimens so that we contribute to the development of various fields ranging from basic life science research to fermentation, food, agriculture, medicine, pharmacy, and diagnostics.

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Project HP URL：https://metabolome.iab.keio.ac.jp/ja/
Publication

1. Soga, T., "Advances in capillary electrophoresis mass spectrometry for metabolomics" Trends Anal. Chem.158, 116883, 2023.
2. J. Chromatogr. A 1652, 462355. (2021)

3. Anal. Chem. 92, 9799-9806. (2020)
4. J. Chromatogr. A 1619, 460914. (2020)
5. Electrophoresis 39, 1382-1389. (2018)
6. J. Chromatogr. A 1369, 161-169. (2014)
7. Analyst 137, 5026-5033. (2012)
8. Anal. Chem. 81, 6165-6174. (2009)
9. J. Biol. Chem. 281, 16768-16776. (2006)
10. J. Proteome Res. 2, 488-494. (2003)
11. Anal. Chem., 74, 2233-2239. (2002)

Akiyoshi Hirayama
Associate Professor

Tomoyoshi Soga
Project Professor