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Molecular Anhydrobiology Project
Water is an essential solvent for all living systems. However, some organisms, including the microscopic microscopic eight-legged animals called the tardigrades, can survive almost complete desiccation by entering an ametabolic state called anhydrobiosis (life-without-water), and they can quickly return to active life upon rehydration. In this state of suspended animation, tardigrades are known for their extremotolerance, exemplified by their survival after ten days of direct exposure to space vacuum. We conduct multi-comics analyses coupled with advanced molecular biology experiments to uncover the molecular mechanisms underlying anhydrobiosis, and we aim to understand the systematic mechanisms enabling extremotolerance in these species.
Publication
- Annu Rev Anim Biosci.10:17-37. (2022)
- Zoologica Scripta. 50(3): 376-382. (2021)
- BMC Genomics. 22(1):813. (2021)
- Sci Rep. 11(1):21328. (2021)
- Molecular Cell. 81(3):409-410. (2021)
- Proceedings of the Royal Society B. 285(1892):20182180. (2018)
- PLoS Biol. 15(7):e2002266. (2017)
- PNAS. 113(22):E3057. (2016)
- Nat Commun. 7:12808. (2016)
Kazuharu Arakawa
Assistant Director, Professor
Sae Tanaka
Staff
- List of research projects
- Molecular Anhydrobiology Project
- Protein Materials Project
- 3D Cell Atlas Project
- Environmental systems biology Project
- Stolen-phenotype biology Project
- Functional RNA Analysis Project
- Bacterial regulatory RNA project
- Synthetic Biology Project
- Bio-Functional Design Project
- Metabolomics Project
- Extracellular vesicle molecular function research Project
- Bioenergetic regulation Project
- DNA damage response Project
- Molecular Oncology Project
- Cancer Metabolism Project
- Tsuruoka Metabolomics Cohort Study (TMCS) Project