Ribosome & Proteomics Project

All of the cells and tissues in our body produce many different forms of proteins, which control metabolism and growth. All of these proteins are produced within cells by the ribosome. The types of proteins being made change under different growth conditions and are also altered by disease mechanisms.
In this project we will use a combination of the traditional biochemical approaches and cutting-edge techniques of Size Exclusion Chromatography and quantitative proteomics to study the ribosomes and the pre-ribosomal particles in mammalian cells. Detailed analysis of the ribosome and its assembly in normal cells and their alterations in the 'stressed' cells provides the basis to discover potential therapeutic targets and/or biomarker in cancers.

Project HP URL：https://sites.google.com/view/iab-yoshikawa-lab
Publication

1. Nat Commun. 14:8200. (2023)
2. Genome Biol. 23:54 (2022)
3. Nucleic Acids Res. 49:6722-6738. (2021)
4. Cell Rep. 35:109032. (2021)
5. eLife. 7:e36530. (2018)
6. Nature. 556:376-380. (2018)
7. Nucleic Acids Res. 45:3437-3447. (2017)
8. Nucleic Acids Res. 43:5524-36. (2015)
9. Mol Cell Proteomics. 10:M110.006148. (2011)
10. Mol Cell Proteomics. 8:1552-65. (2009)

Harunori Yoshikawa
Project Assistant Professor

Yuya Hirooka
Project Researcher