Tsuruoka Metabolomics Cohort Study (TMCS) Project

The Tsuruoka Metabolomics Cohort Study (TMCS) is a population-based cohort study enrolling 11,002 participants since April 2012. This prospective study applies metabolomics technology, including CE/MS for charged metabolites and LC/MS for lipid metabolites, with other omics data such as genomics, to unravel molecular mechanisms underlying complex phenotypes and establish a foundation for personalized disease prevention. Current main topics of TMCS include prevention of cardiovascular diseases, cancer, and age-related functional changes, e.g. frailty, cognitive decline and women's health. Detailed health surveys (wave 1/2/3/4) and follow-up health outcome surveys are conducted on a regular basis. We also develop a pipeline to computationally extract a large amount of uncharacterized peaks in metabolomic data, whose corresponding metabolites are unidentified but some of which may reflect pathophysiology of the subjects.

Publication

1. Maturitas 155:54‐62.(2022)
2. Cancer Epidemiol Biomarkers Prev. 31(1):269‐279.(2022)
3. J Epidemiol. 32;180‐187.(2022)
4. Eur J Prev Cardiol. zwab142.(2021)
5. Sci Rep. 1;11(1):7407.(2021)
6. J Clin Med. 10(9):1826(2021)
7. PLoS One 16(2):e0246456.(2021)
8. PLoS One 13(1): e0191230(2018)
9. PLoS One 11(10): e0164877.(2016)
10. Menopause 23(7):749‐58.(2016)

Toru Takebayashi
Professor

Sei Harada
Assistant Professor

Miho Iida
Assistant Professor
<Regional communication team>
Miki Akiyama

Professor
<Metabolome and Bioinformatics Team>

Akiyoshi Hirayama
Associate Professor
Masahiro Sugimoto
Professor
Rintaro Saito
Project Professor