Drug delivery system project

Drug delivery systems have become indispensable in our lives, but there are still many unrealized challenges, such as the control of intracellular trafficking behavior and its use in other species.
This project aims to develop novel nucleic acid delivery systems using functional peptides to target mitochondria and brown algae through material science, biochemistry, and molecular biology. The systems enable us to elucidate cellular functions induced by the transformation of mitochondrial functions and also breed brown algae with additional functions.

Publication

1. Yoshinaga N, Numata K. (2024) Poly (A) Tail Length of Messenger RNA Regulates Translational Efficiency of the Mitochondria-Targeting Delivery System. ACS Biomaterials Science and Engineering, 10, 10, 6344-6351.
2. Yoshinaga N, Miyamoto T, Goto M, Tanaka A, Numata K. (2024) Phenylboronic Acid-Functionalized Micelles Dual-Targeting Boronic Acid Transporter and Polysaccharides for siRNA Delivery into Brown Algae. JACS Au, 4, 4, 1385-1395.
3. Yoshinaga N, Miyamoto T, Odahara M, Takeda-Kamiya N, Toyooka K, Nara S, Nishimura H, Ling F, Su'etsugu M, Yoshida M, Numata K, (2024) Design of an Artificial Peptide Inspired by Transmembrane Mitochondrial Protein for Escorting Exogenous DNA into the Mitochondria to Restore their Functions by Simultaneous Multiple Gene Expression. Adv. Funct. Mater. 34, 2306070.
4. Yoshinaga N, Numata K. (2022) Rational Designs at the Forefront of Mitochondria-Targeted Gene Delivery: Recent Progress and Future Perspectives. ACS Biomaterials Science and Engineering, 8, 2, 348-359.

Keiji Numata
Project Professor

Naoto Yoshinaga
Project Research Associate