Extracellular vesicle molecular function research Project

Extracellular vesicles (diameter less than one μm) are released from cells and are included in all body fluids, such as blood and urine. Extracellular vesicles function in intercellular communication for immunity, nutritional starvation, cancer cell survival, and the acquisition of resistance to anticancer drugs. We have developed techniques for measuring metabolites in extracellular vesicles and have successfully detected approximately 630 metabolites from the extracellular vesicles of cancer cells. In this project, we aim to elucidate the pathological roles of extracellular vesicles in various diseases at the molecular level by using a trans-omics approach that combines metabolome analysis with other omics analysis.

Publication

1. Frontiers in Molucular Biosciences 9:1049402.(2023).
2. Analytical Chemistry; 94: 13676-13681.(2022).
3. Metabolites 11: 215 (2021).
4. PLoS ONE 15: e0231430 (2020).

Akiyoshi Hirayama
Associate Professor

Ryosuke Hayasaka
Project Researcher