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Extracellular vesicle molecular function research Project
Extracellular vesicles (diameter less than one μm) are released from cells and are included in all body fluids, such as blood and urine. Extracellular vesicles function in intercellular communication for immunity, nutritional starvation, cancer cell survival, and the acquisition of resistance to anticancer drugs. We have developed techniques for measuring metabolites in extracellular vesicles and have successfully detected approximately 630 metabolites from the extracellular vesicles of cancer cells. In this project, we aim to elucidate the pathological roles of extracellular vesicles in various diseases at the molecular level by using a trans-omics approach that combines metabolome analysis with other omics analysis.
Publication
Akiyoshi Hirayama
Associate Professor
- List of research projects
- Molecular Anhydrobiology Project
- Protein Materials Project
- 3D Cell Atlas Project
- Environmental systems biology Project
- Stolen-phenotype biology Project
- Functional RNA Analysis Project
- Bacterial regulatory RNA project
- Synthetic Biology Project
- Bio-Functional Design Project
- Metabolomics Project
- Extracellular vesicle molecular function research Project
- Bioenergetic regulation Project
- DNA damage response Project
- Molecular Oncology Project
- Cancer Metabolism Project
- Tsuruoka Metabolomics Cohort Study (TMCS) Project