Bioenergetic regulation Project

ATP is a well-known bioenergy, and its depletion means the end of vital activity. Conversely, depletion of GTP, a similar energy molecule to ATP, causes different reactions, such as cellular dormancy; genetic mutations in the GTP synthesis pathway result in mental illness, vision loss, and immune depression. However, mechanisms of bioenergetic regulation remain largely unknown. We aim to elucidate the bioenergetic regulatory system through a multidisciplinary approach, using metabolic analysis and collaboration with national and international teams. We aim to identify the mechanistic roles of bioenergy molecules in cancer, metabolic diseases, and aging and develop new treatments for diseases.

Publication

1.Structure. 2022 Jun 2;30(6):886-899.e4.
2.Front Mol Biosci. 2021 Jul 8;8:707439. doi: 10.3389/fmolb.2021.707439. eCollection 2021.
3. J Biochem. 2022 Jan 7;170(6):699-711
4.Front Oncol. 2020 Nov 2;10:554272
5.J Biochem. 2020 Oct 1;168(4):319-328.
6.Cancers (Basel). 2019 Sep 11;11(9):1346.
7.Nat Cell Biol. 2019 Aug;21(8):1003-1014.
8.FEBS J. 2016 Oct;283(19):3556-3562. doi: 10.1111/febs.13739.
9.Mol Cell. 2016 Jan 21;61(2):187-98.

Tomoyoshi Soga
Professor

Atsuo Sasaki
Project Professor

GTP GEEKS:https://www.gtp-project.net/
The Sasaki Lab:http://thesasakilab.org/

Akiyoshi Hirayama
Associate Professor