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Cancer Metabolism Project
Metabolic reprogramming of cancer, which was discovered by Warburg 100 years ago, has been revised as one of the important features of cancer and has been vigorously studied in recent years. It has been found that cancer cells produce substances required by cancer cells by enhancing not only ATP but also nucleic acid synthesis, protein synthesis, lipid synthesis pathways, glutamine metabolism, glutathione metabolism, methionine metabolism, one-carbon metabolism, and other metabolic pathways through aerobic glycolysis. In recent years, new findings have emerged that branched-chain amino acids are involved in the maintenance of cancer stem cells and that metabolites produced by cancer cells regulate the differentiation and activation of immune cells. This project aims to elucidate the metabolic pathways and molecular mechanisms that are specifically enhanced during the proliferation, metastasis, and invasion of various types of cancer, and to develop new anticancer drugs and therapies.
Publication
- Commun. Biol. 5:403. (2022)
- Sci. Adv. 8:eabf9096. (2022)
- Sci. Rep. 11:21353. (2021)
- Commun Biol. 4:782. (2021)
- BMC Cancer 21:174. (2021)
- Nature 569:275-279. (2019)
- Proc. Natl. Acad. Sci. USA 114:E7697-E7706. (2017)
- Cell Rep. 3:1440-1448. (2013)
- Cancer Cell 20:524-537. (2011)
- Cancer Res. 69: 4918-4925. (2009)
Tomoyoshi Soga
Professor
Shojiro Kitajima
Project Assistant Professor
Yasuhiro Saito
Project Associate Professor
- List of research projects
- Molecular Anhydrobiology Project
- Protein Materials Project
- 3D Cell Atlas Project
- Environmental systems biology Project
- Stolen-phenotype biology Project
- Functional RNA Analysis Project
- Bacterial regulatory RNA project
- Synthetic Biology Project
- Bio-Functional Design Project
- Metabolomics Project
- Extracellular vesicle molecular function research Project
- Bioenergetic regulation Project
- DNA damage response Project
- Molecular Oncology Project
- Cancer Metabolism Project
- Tsuruoka Metabolomics Cohort Study (TMCS) Project